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Current Treatments Using Cord Blood Stem Cells...

 

Treatable Diseases and Future Uses of Umbilical Cord Blood Stem Cells

Today, cord blood stems cells are used in the treatment of over 70 life-threatening diseases, including a wide range of cancers, genetic diseases, immune system deficiencies, and blood disorders (see list below).

 

 Cancers 

· Acute lymphoblastic leukemia (ALL)

· Acute myeloid leukemia (AML)

· Burkitt's lymphoma

· Chronic myeloid leukemia (CML)

· Juvenile myelomonocytic leukemia (JMML)

· Hemophagocytic lymphohistiocytosis

· Non-Hodgkin's lymphoma

· Hodgkin's lymphoma

· Langerhan's cell histiocytosis

· Lymphomatoid granulomatosis

· Myelodysplastic syndrome (MDS)

· Chronic myelomonocytic leukemia (CMML)

 

Bone Marrow Failure Syndromes  

· Amegarakyocytic thrombocytopenia

· Autoimmune neutropenia (severe)

· Congenital dyserythropoietic anemia

· Cyclic neutropenia 

· Diamond-Blackfan anemia

· Evan's syndrome

· Fanconi anemia

· Glanzmann's disease

· Juvenile dermatomyositis

· Kostmann's syndrome

· Red cell aplasia

· Schwachman syndrome

· Severe aplastic anemia

· Congenital sideroblastic anemia

· Thrombocytopenia with absent radius (TAR syndrome)

· Dyskeratosis congenital

 

Blood Disorders/Hemoglobinpathies 

· Sickle-cell anemia (hemoglobin SS)

· HbSC disease

· Sickle β^o Thalassemia

· α-thalassemia major (hydrops fetalis)

· β-thalassemia major (Cooley's anemia)

· β-thalassemia intermedia

· E-β^o thalassemia

· E-β+ thalassemia

 

Metabolic Disorders  

· Adrenoleukodystrophy

· Gaucher's disease (infantile)

· Metachromatic leukodystrophy

· Krabbe disease (globoid cell leukodystrophy)

· Gunther disease

· Hermansky-Pudlak syndrome

· Hurler syndrome 

· Hurler-Scheie syndrome

· Hunter syndrome

· Sanfilippo syndrome

· Maroteaux-Lamy syndrome

· Mucolipidosis Type II, III

· Alpha mannosidosis

· Neumann Pick Syndrome, type A and B

· Sandoff Syndrome

· Tay Sachs Disease

· Batten disease (inherited neuronal ceroid lipofuscinosis)

 

Immunodeficiencies 

· Ataxia telangectasia

· Chronic granulomatous disease

· DiGeorge syndrome

· IKK gamma deficiency

· Immune dysregulation polyendocrineopathy X-linked

· Mucolipidosis, Type II

· Myelokathesis

· X-linked immunodeficiency

· Severe combined immunodeficiency

· Adenosine desaminase deficiency

· Wiskott-Aldrich syndrome

· X-linked agammaglobulinemia

· X-linked lymphoproliferative disease

· Omenn's syndrome

· Reticular dysplasia

· Thymic dysplasia

· Leukocyte adhesion deficiency

 

Other 

· Osteopetrosis

 

 

Although the potential use of umbilical cord blood is expanding rapidly, the odds that family member without a defined risk will need to use their child's umbilical cord blood are low. There is no guarantee that the umbilical cord blood will be a match for a family member or will provide a cure. Autologous cord blood stem cells will not guarantee suitable treatment for all inherited genetic diseases. As with any transplant therapy, therapeutic success depends upon many factors beyond the stem cells themselves including patient condition, type of disease, recipient-donor relationship and matching, and other factors.

 

 

 

 

 

 

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